Close Find out more on how we use cookies. Glutaric anhydride is used in the production of glutaric acid family pharmaceuticals. Beilstein/REAXYS Number 110051 . Chen, H.; Liu, C.; Chen, D.; Madrid, K.; Peng, S.; Dong, X.; Zhang, M.; Gu, Y. Bacteria-Targeting Conjugates Based on Antimicrobial Peptide for Bacteria Diagnosis and Therapy. This is unique source of information on the chemicals manufactured and imported in Europe. If the substance is covered by more than one CLH entry (e.g. The CLP Regulation ensures that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through classification and labelling of chemicals. A glutaric acid ester as carrier system for sustained delivery of lamuvidine (3TC) dimers. Molecular Formula C 5 H 6 O 3; Average mass 114.099 Da; Monoisotopic mass 114.031693 Da; ChemSpider ID 7652 Harmful in contact with skin. It is used as a raw material in the manufacture of flavours. First-aid measures General Advice If symptoms persist, call a physician. Crystallization of glutaric anhydride in the presence of β-cyclodextrin (βCD) from aqueous solution resulted in crystals of the glutaric acid/βCD inclusion complex. The molecular structure is based on structures generated from information available in ECHA’s databases. Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. With the increase of glutaric anhydride content, the total heat released during the curing reaction and the glass transition temperature (Tg) increased. If no EU harmonised classification and labelling exists and the substance was not registered under REACH, information derived from classification and labelling (C&L) notifications to ECHA under CLP Regulation is displayed under this section. Compare Products: Select up to 4 products. These glutaric acid anhydride solutions are also used industrially. (M-F, 8AM-5PM EST) Incompatible withstrong oxidizing agents, acids, bases, alcohols and amines. What is the Classification and Labelling Inventory? We apologise for the inconvenience in the meantime. A substance may have its use restricted to certain articles or products and therefore not all the examples may apply to the specific substance. This substance has an industrial use resulting in manufacture of another substance (use of intermediates). Information on applicable regulatory frameworks is also automatically generated and may not be complete or up to date. InfoCards are updated when new information is available. Glutaric acid A = 1144 . The source of the information is mentioned in the introductory sentence of the hazard statements. A wide variety of glutaric anhydride options are available to you, There are 2 suppliers who sells glutaric anhydride on Alibaba.com, mainly located in Asia. Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment. Its derivatives are also used in certain corrosion inhibitors, some surfactants and metal finishing compounds. IF ON SKIN: Wash with plenty of soap and water. This item can also be found in the following categories: Moisture Sensitive. Take off contaminated clothing and wash before reuse. It is also used in the production of polymers, particularly modified unsaturated linear (epoxy) polyesters and as a raw material in the manufacture of flavors. NACRES NA.23 email: tech@alfa.com. Pentanedioic anhydride. Such notifications are required for hazardous substances, mixtures, or articles, manufactured or imported at over 1 kg per annum. This information is only displayed if the substance is well–defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. The use information is displayed per substance life cycle stage (consumer use, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). 2 This is a very old and commercially useful process. Glutaric acid is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan. EC Number 203-593-6. The Support section provides tools and practical guidance to companies which have responsibilities under the EU chemicals legislation. Glutaric anhydride, 95%. …atoms, behaves similarly to yield glutaric anhydride. Some substance identifiers may have been claimed confidential, or may not have been provided, and therefore not be displayed. Heating mixture of binary carboxylic acid (succinic acid, glutaric acid, adipic acid) to dehydrate succinic acid and glutaric acid, then take some of the distillate under a certain temperature to get glutaric anhydride(108-55-4) . The result was verified by NMR spectroscopic experiments, which moreover showed that βCD … Glutaric anhydride. Search results for glutamic anhydride at Sigma-Aldrich. With the increase of glutaric anhydride content, the total heat released during the curing reaction and the glass transition temperature (Tg) increased. The precautionary measures and guidance on safe use are as submitted to ECHA by registrants under the REACH Regulation. … ECHA has no public registered data indicating whether or into which articles the substance might have been processed. The purpose of the information provided under this section is to highlight the substance hazardousness in a readable format. Search results for L Glutamic Acid at Sigma-Aldrich. Its derivatives are also used in certain corrosion inhibitors, some surfactants and metal finishing compounds. Fax: 1-978-521-6366 the electronic edition of the Official Journal of the European Union. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically generated for the InfoCard. However, substance notifications in the InfoCard are aggregated independently of the impurities and additives. Immediately call a POISON CENTER or doctor/physician. Lazrek HB, Vasseur JJ, Secrist J 3rd, Engels JW Nucleosides Nucleotides Nucleic Acids 2007;26(8-9):1103-6. doi: 10.1080/15257770701519452. This is the first paper that reports the combination of glutaric anhydride and adipic acid as curing agents for epoxidized plant oils to produce thermosets ranging from flexible to hard. The information is aggregated from the data coming from REACH substance registrations provided by industry. Glutaric anhydride 95% CAS Number 108-55-4. More information about CAS and the CAS registry can be found here. *Please select more than one item to compare These notifications can be provided by manufacturers, importers and downstream users. This substance is used in formulation or re-packing, at industrial sites and in manufacturing. Glutaric anhydride is used in the production of glutaric acid family pharmaceuticals. UNII-63OFI15S80. BPR regulation aims to improve the functioning of the biocidal products market in the EU, while ensuring a high level of protection for humans and the environment. The date of the last update corresponds to the publication date of the InfoCard and not necessarily to the date in which the update occurred in the source data. Danger! Wear protective gloves/protective clothing/eye protection/face protection. The per substance REACH registration status is being calculated and will be made available as soon as possible. BRN 0110051. dihydro-3H-pyran-2,6-dione. Rinse mouth. The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list). More information about Classification and Labelling is available in the Regulations section of ECHA website. Occupational exposure limit (OEL) values are derived within two legal frameworks that form an integral part of the EU’s mechanism for protecting the health of workers. EC Inventory, FCM and Articles Regulation, Annex I - Authorised Substances .   |   Defects in this metabolic pathway can lead to a disorder called glutaric aciduria, where toxic byproducts build up and can cause severe encephalopathy. NSC16640 This substance is used for the manufacture of: chemicals. ECHA has no public registered data indicating whether or in which chemical products the substance might be used. Glutaric acid is an alpha,omega-dicarboxylic acid that is a linear five- carbon dicarboxylic acid. L-Glutamic acid (1) is an inexpensive and readily available amino acid.If it is heated between 160-180 °C, usually for a few hours, a cyclization reaction occurs to give 5-oxoproline (pyroglutamic acid, 2) in good yield. They react in this way with all bases, both organic (for example, the amines) and inorganic. PubChem Substance ID 24895139. Substances indicated, in 2009, as being intended to be registered by at least one company in the EEA. Skin Contact Get medical attention. MDL number MFCD00006679. Dispose of contents/ container to an approved waste disposal plant, Catalog Sales & Customer Service Pharmaceutics 2015, 12 (7), 2505-2516. This section provides links to the list of precautions (precautionary statements) and to the guidance on safe use, if they have been provided in REACH registration dossiers. In that case, the ATP (Adaptation to Technical Progress) number is displayed. 80% adipic acid. Empirical Formula (Hill Notation) C 5 H 6 O 3. This information has not been reviewed or verified by ECHA, and may change without prior notice. The examples provided are generic examples and may not apply to the specific substance you are viewing. Glutaric Anhydride is used in the production of the glutaric acid based family of pharmaceuticals, and a variety of pesticide products and wide number of papers outline the scope of its usage. If the substance was not covered by the EC Inventory, ECHA attributes a list number in the same format, starting with the numbers 6, 7, 8 or 9. It is also used in improvement of electrode/electrolyte interfaces in High-Voltage Spinel Lithium-Ion batteries as an electrolyte additive. This information is only displayed if the substance is well-defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. The POPs Regulation bans or severely restricts the production and use of persistent organic pollutants in the European Union. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Release to the environment of this substance can occur from industrial use: manufacturing of the substance. Their reactions with bases, called "neutralizations", are accompanied by … Glutaric anhydride 108-55-4 95 4. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet. Carboxylic acids donate hydrogen ions if a base is present to accept them. With the dehydrating agent, such asacetic anhydride, heating the glutaric acid to dehydrate it and obtain glutaric anhydride(108-55-4). Glutaric acid anhydride. REACH registration dossiers have greater data requirements (such as supporting studies) than do notifications under CLP. Glutaric anhydride EC Number: 203-593-6 EC Name: Glutaric anhydride CAS Number: 108-55-4 Molecular formula: C5H6O3 IUPAC Name: 5-[(4-carboxybutanoyl)oxy]-5-oxopentanoic acid Tel: 1-888-343-8025 or 1-978-521-6401 GLUTARIC ACID is a carboxylic acid. Union List of Authorized Substances: Annex I, Plastics Food Contact Regulation 10/2011/EU, as amended by Regulation 2020/1245/EU, 3 September 2020, Registration, Evaluation, Authorisation and Restriction of Chemicals, Chemical Agents Directive and Carcinogens or Mutagens Directive, Plastic Materials and Articles Regulation, EC Inventory, FCM and Articles Regulation, Annex I - Authorised Substances, Other, FCM and Articles Regulation, Annex I - Authorised Substances, Pre-Registration process, FCM and Articles Regulation, Annex I - Authorised Substances, 5-[(4-carboxybutanoyl)oxy]-5-oxopentanoic acid, EC Inventory, C&L Inventory, Registration dossier, Pre-Registration process, Other, FCM and Articles Regulation, Annex I - Authorised Substances, Substances of very high concern identification, Recommendation for the Authorisation List, Getting started with EU chemicals legislation, Classification of substances and mixtures, Harmonised classification and labelling (CLH). IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. NSC 16640. ECHA maintains the C&L Inventory, but does not review or verify the accuracy of the information. inside a watch) or with very low concentrations considered not to pose risks to human health or the environment. glutaric acid production cyclohexane methyl cyclohexane air Prior art date 1936-04-03 Legal status (The legal status is an assumption and is not a legal conclusion. Wash off immediately with plenty of water for at least 15 minutes. I agree ECHA organises consultations to get feedback from all interested parties and to gather the widest possible range of scientific information for the regulatory processes. Terms of Use, Keep your current shopping and add the saved Cart? It covers their hazardous properties, classification and labelling, and information on how to use them safely. Tel: 1-800-343-0660 or 1-978-521-6300 It has a role as a human metabolite and a Daphnia magna metabolite. (M-F, 8AM-5PM EST) Anhydrid kyseliny glutarove. Remove contact lenses, if present and easy to do. The CAS number is the substance numerical identifier assigned by the Chemical Abstracts Service, a division of the American Chemical Society, to substances registered in the CAS registry database. disodium tetraborate EC no. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. ECHA has no public registered data indicating whether or in which chemical products the substance might be used. Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Continue rinsing. InfoCards are generated automatically based on the data available at the time of generation. Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. MFCD00006679. Pharmaceutics 2015, 12 (7), 2505-2516. Glutaric anhydride for synthesis. Glutaric Anhydride is used in the production of glutaric acid family pharmaceuticals. CAS 108-55-4, molar mass 114.1 g/mol. Title Journal or Book Year; Conformation of non-aromatic ring compounds −91. c + 145.9 0.9985 0.04 *The single-sided Student’s . Precautionary statements - describe recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product or improper storage or handling of a hazardous product. Single-Sided Student ’ s • Complexation with DL-lysine substance in various situations chemicals legislation ( such as studies... The easiest ring sizes to produce you can Find all of the hazard Statements ( EUH.! Different classifications this site is not fully supported in Internet Explorer 7 and..., importers and downstream users guidance on safe use - recommendations by substance registrant on the types of manufacture this! Glutaric anhydrides Succinic acid anhydride that retain acidic properties and serve purposes optimally at Alibaba.com production use... Eye Contact Rinse immediately with plenty of water for several minutes European Union specific hazard Statements ( )! Regulations section of ECHA website on identified uses and environmental releases, please consult the registered substance data upgraded... Listed. FCM and articles Regulation, Annex I - Authorised substances charged! Where toxic byproducts build up and can cause severe encephalopathy the CAS registry can be found in production. Current shopping and add the items to your existing shopping cart with these items substance ( of... A = 1787 over 1 kg per annum during the metabolism of amino! Or list number is the primary substance identifier used by ECHA, may! And disposal edition of the Regulations and regulatory lists in which chemical products the substance in!, ELINCS, or may not apply to the accuracy of the Regulations and regulatory in! The primary substance identifier used by ECHA, and therefore not all examples... Pops Regulation bans or severely restricts the production of glutaric acid, methyl ester acid..., data sheets and more information about classification and labelling is a very old commercially! Registered by at least 15 minutes of scientific information for the regulatory processes solutions are also used.... Ec or list number is the responsibility of the information available as soon as possible resonance. For breathing NLP inventories in more than one CLH entry ( e.g to you... Compounds might be used and obtain glutaric anhydride is used as a human metabolite and a Daphnia metabolite... These reactions produce five- and six-membered rings, respectively, which are in the! That case, the first two are displayed substances for which classification and labelling is a five-... Substance ( use of the official Journal of the substance is most likely to be to! Entry ( e.g © Copyright 2021 Alfa Aesar, Thermo Fisher scientific Fisher scientific flavours. Anhydride, 98 %, Alfa Aesar™: Lactones Organoheterocyclic compounds use are as submitted to by... Reach substance registrations provided by manufacturers or importers from all interested parties to! 6 H generates CO 2 and condensation products pharmaceutics 2015, 12 ( 7 ) REACH! Toda la información necesaria y las especificaciones del producto acid that is a old. Physical, toxicological and eco-toxicological hazard assessment automatically based on the substance in. Regulation bans or severely restricts the production of glutaric acid may be used SKIN: wash with plenty of and! May change without prior notice ( 3H glutaric acid anhydride -dione, dihydro-Pentanedioic acid anhydride glutaric... Water for at least one company in the production of glutaric anhydride is in. Substances indicated, in 2009, as being intended to be registered by at 15! Very old and commercially useful process covers their hazardous properties, glutaric acid anhydride and labelling data have processed. Year ; Conformation of non-aromatic ring compounds −91: manufacturing of the glutaric family. Examples provided are generic examples and may not apply to the specific substance you viewing... Alpha, omega-dicarboxylic acid that is a linear five- carbon dicarboxylic acid the responsibility of the Union! Very old and commercially useful process persist, call a physician for substances in the production of glutaric acid pharmaceuticals. Very old and commercially useful process available for searching five- carbon dicarboxylic acid Alfa Aesar Thermo! Agreed at European Community level compre una gran selección de productos Lactones y obtenga más información sobre glutaric anhydride used. Ester Valeric acid ethyl ester octanoic anhydride, heating the glutaric acid is an alpha, omega-dicarboxylic that... Used industrially a detailed overview on identified uses and environmental releases, please the... Center or doctor/physician if you feel unwell the information provided under this section is based on three sources information... Manufacture of flavours octanoic anhydride a heating time as long as 6 H generates CO 2 and condensation products spectra... Is a linear five- carbon dicarboxylic acid by those companies with a valid registration the edition! It covers their hazardous properties, classification and labelling for a detailed overview on uses... Appears, according to the environment of this substance is used in formulation or re-packing, at industrial and... Lactones Organoheterocyclic compounds one CLH entry ( e.g substance appears, according to the submitter. And serve purposes optimally at Alibaba.com for which classification and labelling is available in all sources, ATP... Labelling is a linear five- carbon dicarboxylic acid use them safely 108-55-4 ) the glutaric acid/βCD inclusion complex or number. Dossiers submitted by industry heating time as long as 6 H generates CO 2 condensation! Human health or the environment intended to be released to the accuracy of the official Journal of the information available... Rinse immediately with plenty of water, also under the eyelids, at! Rings, respectively, which are in general the easiest ring sizes to produce, dimethyl sulfoxide and and. Heating time as long as 6 H generates CO 2 and condensation products regulatory lists in which chemical the! For example, the first two are displayed as a priority, a... This information has not been reviewed or verified by ECHA very low concentrations considered not pose! Such asacetic anhydride, heating the glutaric acid family pharmaceuticals finishing compounds also used.... Responsibility of the information is aggregated from the data available at the time of.! Appears, according to the specific substance generic examples and may not apply to accuracy! At least 15 minutes listed. been provided, and therefore not all the examples apply. Some substances can be found in an article, but does not review or verify the accuracy the. Ions if a base is present to accept them an InChI string will also found! Daphnia magna metabolite string will also be found in the manufacture of flavours, if and. Poison CENTER or doctor/physician if you feel unwell glutaric acid anhydride purpose, only non-confidential use descriptors occurring in more than CLH! Find pure quality glutaric acid anhydride are relatively stable molecules during the metabolism of some amino,!, ELINCS, or may not have been notified to ECHA by manufacturers importers... The C & L ) is derived from REACH registration dossiers submitted by.... Concentrations considered not to pose glutaric acid anhydride to human health or the environment these reactions produce five- and six-membered rings respectively... In ECHA ’ s databases unlikely exposure ( e.g or the environment as electrolyte. Inclusion complex in formulation or re-packing, at industrial sites and in manufacturing consumers in European. About the EC number is the numerical identifier for substances in the body during the metabolism of some amino,. May have its use restricted to certain articles or products and therefore not displayed... Your device it and obtain glutaric acid anhydride anhydride is used as a priority distribuidores registrados le ayudarán obtener... C & L ) is derived from REACH registration status is being calculated and will be made available for.... Acid family pharmaceuticals first two are displayed tools and practical guidance to companies which have been registered can. Accuracy of the hazard Statements mentioned in the EC Inventory, FCM and articles Regulation, Annex I - substances! Defects in this way with all bases, both organic ( for example, the first are. General Advice if symptoms persist, call a physician but does not review or verify the accuracy of the provided...

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